Bioanalysis

With Bioanalysis, accuracy and sensitivity is critical. We provide a wide range of bioanalytical services.

With our expert team and state of the art equipment, we offer novel analytical techniques to accomplish our clients’ objectives. Our array of techniques includes the proprietary derivatizing agent – SymDaq – allowing for analysis of low concentrations of multiple neurotransmitters simultaneously in a single run.

Measuring multiple neurotransmitters

Situation:

Client needed to identify a pharmacodynamic measurement for their compound, but didn’t know where to start.

Approach:

We designed a program to leverage our SymDaq extraction method for increased accuracy and sensitivity in LC-MS/MS detection, as well as lower sample volumes, and enhanced overall sensitivity and efficiency.

Key Challenge:

To measure multiple neurotransmitters in the mouse brain.

Result:

We were able to identify specific changes in low levels of one of the 18 transmitters measured, allowing our client to better understand the mechanistic changes evoked by their compounds. This data aided in compound selection, as well as further clinical development.

Customized Solutions

We can develop novel procedure designs, based on your specific needs, for sample preparation, and quantification and analysis of samples, either generated in-house or client-provided. As with all our services, we provide total quality assurance of all analyzed data as part of the final report. 

Biological matrices include:

  • CSF samples
  • Microdialysates
  • Brain tissue samples
  • Plasma, plasma free fraction or serum
  • In vitro matrices
  • Urine
  • Bone
  • Gut tissue
  • Liver
  • Kidney
  • Spleen
  • Human tissue (non-glp)
  • Other biological tissues
  • Other biological fluids

Existing analyses include:

  • Acetylcholine
  • Amino acids (incl. GABA)
  • cAMP/cGMP
  • Glucose and lactate
  • Histamine
  • Monoamines (incl. NE, DA, 5HT)
  • Exogenous compounds
  • Glucocorticoids
  • Kynurenines
  • Tryptophan
  • MA metabolites (incl. HVA, 5-HIAA, DOPAC)
  • D- and L- Serine
  • Polyamines (incl. putricine, spermine)

Let's talk

More than just microdialysis, we offer a full suite of services that can be tailored specifically to your needs and preferences.

Think of us as an extension of your lab, adhering to the highest standards of quality and scientific integrity, while taking utmost care with your data, your budget, and your time.

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